| DATE | HOME | SCORE | AWAY | |||
|---|---|---|---|---|---|---|
| 25/09/2021 |  | DEPORTIVO ALAVÉS | 1 - 0 | ATLÉTICO MADRID |  | |
| 25/09/2021 |  | VALENCIA | 1 - 1 | ATHLETIC BILBAO |  | |
| 25/09/2021 |  | SEVILLA | 2 - 0 | ESPANYOL |  | |
| 25/09/2021 |  | REAL MADRID | 0 - 0 | VILLARREAL |  | |
| 26/09/2021 |  | MALLORCA | 2 - 3 | OSASUNA |  | |
| 26/09/2021 |  | BARCELONA | 3 - 0 | LEVANTE |  | |
| 26/09/2021 |  | REAL SOCIEDAD | 1 - 0 | ELCHE |  | |
| 26/09/2021 |  | RAYO VALLECANO | 3 - 1 | CÁDIZ |  | |
| 26/09/2021 |  | REAL BETIS | 2 - 0 | GETAFE |  | |
| 27/09/2021 |  | CELTA DE VIGO | 1 - 0 | GRANADA |  |
