| DATE | HOME | SCORE | AWAY | |||
|---|---|---|---|---|---|---|
| 22/10/2021 |  | OSASUNA | 1 - 1 | GRANADA |  | |
| 23/10/2021 |  | VALENCIA | 2 - 2 | MALLORCA |  | |
| 23/10/2021 |  | CÁDIZ | 0 - 2 | DEPORTIVO ALAVÉS |  | |
| 23/10/2021 |  | ELCHE | 2 - 2 | ESPANYOL |  | |
| 23/10/2021 |  | ATHLETIC BILBAO | 2 - 1 | VILLARREAL |  | |
| 24/10/2021 |  | SEVILLA | 5 - 3 | LEVANTE |  | |
| 24/10/2021 |  | BARCELONA | 1 - 2 | REAL MADRID |  | |
| 24/10/2021 |  | REAL BETIS | 3 - 2 | RAYO VALLECANO |  | |
| 24/10/2021 |  | ATLÉTICO MADRID | 2 - 2 | REAL SOCIEDAD |  | |
| 25/10/2021 |  | GETAFE | 0 - 3 | CELTA DE VIGO |  |
